Pharmacological Activity of Synthetic Piperidine against Bacterial Isolates of Cigarette Smoking Men

Yasodha T | Nandhitha G

Abstract: Piperidine is a saturated heterocyclic ring, considered as a privileged scaffold in view of its role in wide range of biological activities. The planar nature of this heterocyclic nucleus allows the introduction of substituent groups at different positions on the ring. In the present study, 3-allyl 2, 6-bis (4-fluorophenyl) piperidine-4-one had been synthesized and its antibacterial activity was assessed. Piperidine, either from the natural sources or in the synthetic form attracted many researchers due to its antioxidant, antiplatelet, anti-inflammatory, antihypertensive, antihelminthic, antitumor, and antiasthmatic activities. Synthesis of 3-allyl 2, 6-bis (4-fluorophenyl) piperidine-4-one revealed a new horizon towards the pharmacological actions against the bacterial flora of cigarette smoking persons. The promising pharmacological activity at 25mg/ml concentration against bacterial isolates had shown the greater zone of inhibition ranging from 20.1 to 26 mm for E. coli, 22-24mm for Staphylococcus aureus, 23.3-26.4 mm for Bacillus subtilis, 24.7-27.5mm for Streptococcus spand 24.8-28 for Pseudomonas aeurigenosa. The present investigation on antibacterial activity of the synthetic piperidine against the pathogenic bacteria of cigarette smoking persons demonstrated synthetic piperidine is a suitable candidate for pharmacological formulations.

Keywords: Piperidine, Synthesis, cigarette smokers, bacterial isolates, antibacterial activity

Edition: Volume 13 Issue 2, February 2024,

Pages: 16 - 19