Study of Serum Creatinine and Serum Uric Acid in Subclinical and Overt Hypothyroid Patients

M. S. Yamini, Simant Baliar Singh

Abstract: Background: The relationship between hypothyroidism and kidney dysfunction is complex.The paucity of Indian data highlighting the effect of inadequate thyroid hormones on renal function led us to study in order to examine potential mechanistic links between thyroid and kidney disease in this sub-population. To study Serum creatinine and Serum Uric acid and correlate with TSH,FT3,FT4 in subclinical and overt hypothyroid patients. Material and Methods: A Cross-Sectional Study was conducted on patients who are diagnosed with hypothyroidism in OPD of the Department of General Medicine of ESIC MC, Rajajinagar Bangalore-10. Study was conducted on 96 Hypothyroid patients. Serum TSH, FT3, FT4 were analysed by using chemiluminescence immunoassay from Beckman coulter. Serum Creatinine by modified Jaffe?s method, Serum Uric acid by uricase method were analysed using COBAS INTEGRA 400 PLUS. Results: In our study there is statistically significant, positive correlation between S.Creatinine and TSH in hypothyroid groups (R=0.60, p=<0.0001). There is positive correlation between S.uric acid and TSH which is statistically significant (r= 0.36, P= 0.0002)and there is negative correlation between FT4 and S.uric acid and statistically significant.( r=-0.25, P= 0.01)We found that with increase in Serum TSH level, decrease in FT3 and FT4 there is increase in Serum creatinine level. We also found Serum Uric acid level increased with increase in Serum TSH level. Conclusion: There is increased serum creatinine and Serum uric acid with increased Serum TSH level in hypothyroid patients. This points toward possible role of these renal parameters in the etiopathogenesis of kidney disorders. Hence, Serum creatinine, Serum Uric acid might be used as additional parameters in hypothyroid patients to prevent kidney related disorders.

Keywords: Hypothyroidism, Creatinine, Uric acid