The Serotonin Hypothesis: An Umbrella Review of Depression Evidence

M. V. A. N. Varun Sharma, Dr. Ch. P. S. R. Madhuri, Dr. G. Sumalatha

Abstract: Depression, or major depressive disorder (MDD), is a widespread mental health issue characterized by persistent sadness, hopelessness, and diminished interest in daily activities, affecting approximately 264 million individuals globally. It is a leading cause of disability, with regional variations influenced by cultural and socioeconomic factors. The serotonin hypothesis, proposed in the 1960s, suggests that serotonin imbalance in the brain contributes to depression, supported by the efficacy of serotonin - enhancing treatments like SSRIs. Neurobiological, pharmacological, and genetic studies have advanced understanding of serotonin's role in mood regulation. However, depression's complexity necessitates integrating serotonin - based insights with broader biological, psychological, and social frameworks. Emerging therapies and future research priorities, including genetic profiling and novel neuroimaging techniques, aim to improve diagnosis and treatment. An integrative approach offers a more nuanced understanding of depression, emphasizing the interplay between genetic, environmental, and neurochemical factors for advancing mental health care.

Keywords: Depression, Serotonin hypothesis, Mental health, Antidepressants, Mood regulation

How to Cite?: M. V. A. N. Varun Sharma, Dr. Ch. P. S. R. Madhuri, Dr. G. Sumalatha, "The Serotonin Hypothesis: An Umbrella Review of Depression Evidence", Volume 13 Issue 12, December 2024, International Journal of Science and Research (IJSR), Pages: 475-483, https://www.ijsr.net/getabstract.php?paperid=SR241202212221, DOI: https://dx.doi.org/10.21275/SR241202212221