Association of Elevated Lipid Profiles and Fatty Liver Prevalence in Uncontrolled Hypothyroidism: A Case - Control Study

Nivedha J N, Pangajam P, Lakshmi C

Abstract: Nonalcoholic fatty liver disease is a chronic condition due to increased accumulation of fat in the liver in the absence of excess alcohol consumption. Identifying the risk factors and diseases linked to the pathophysiology of fatty liver is important in effectively employing preventive interventions against nonalcoholic fatty liver disease owing to its progressive complications. Hypothyroidism is the common endocrine disease implicated in the derangement of lipid metabolism promoting the development of fatty liver. Aim of the study: The study aims to identify the prevalence of fatty liver in uncontrolled hypothyroid patients and controlled hypothyroid patients and its relation with the lipid profile parameters. Materials and Methodology: A case control study was performed between 25 Uncontrolled hypothyroid patients and 25 controlled hypothyroid patients. Results: The increased levels of lipid profile in uncontrolled hypothyroid group compared to controlled hypothyroid group were statistically significant (p<0.001). The prevalence of fatty liver is 3.5 times increased in uncontrolled hypothyroid group compared to controlled hypothyroid group. Conclusion: The study clearly states that control of hypothyroidism is mandatory to minimize its effect on development of fatty liver.

Keywords: Hypothyroidism, fatty liver, dyslipidemia

How to Cite?: Nivedha J N, Pangajam P, Lakshmi C, "Association of Elevated Lipid Profiles and Fatty Liver Prevalence in Uncontrolled Hypothyroidism: A Case - Control Study", Volume 14 Issue 7, July 2025, International Journal of Science and Research (IJSR), Pages: 250-252, https://www.ijsr.net/getabstract.php?paperid=SR241122100133, DOI: https://dx.doi.org/10.21275/SR241122100133