Downloads: 3 | Views: 46 | Weekly Hits: ⮙1 | Monthly Hits: ⮙2
Research Paper | Medicine | India | Volume 13 Issue 1, January 2024
A Study of Clinical Correlation with Inflammatory Markers in Patients of COPD with Acute Exacerbation
Dr. Dnyaneshwar Suresh Thakare | Dr. Richa Sharma [4]
Abstract: Introduction: The sudden worsening of COPD symptoms, such as shortness of breath, increased sputum volume and color, and systemic inflammation, is known as an acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and it significantly lowers survival rates. Procalcitonin and high-sensitivity C-reactive protein (hsCRP) have been studied as predictive biomarkers in individuals with AECOPD. Two novel inflammatory markers, the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), are important predictors of outcome in AECOPD patients. Hospitalized AECOPD patients may benefit from the use of NLR and PLR, which are readily available, and affordable markers. Aim: Study of inflammatory markers in COPD and their correlation with clinical outcome. Methods: A prospective observational comparative study was conducted on 100 patients of COPD at the Department of General Medicine, Saraswathi Institute of Medical Sciences, Hapur, and all necessary investigations were done. Results: A total of 100 individuals with COPD were included; fifty of them were in a stable state (controls), while the remaining fifty patients were experiencing an acute exacerbation (cases). While PLR levels in patients and controls were similar with no discernible difference, mean levels of NLR, hsCRP, and procalcitonin in cases were considerably higher than in controls. Procalcitonin and hsCRP levels were favorably connected with the levels of these two inflammatory indicators, NLR and PLR. Of the fifty patients, 21 required mechanical ventilation, and 9 required inotropic assistance. Out of 50 patients, only 6 (12.00%) died . The length of hospital stay was significantly correlated with NLR and PLR levels. While PLR was significantly higher in patients who needed mechanical ventilation, NLR and PLR levels were not significantly correlated with either need for inotropic support or mortality. Neither was NLR significantly correlated with the requirement for mechanical ventilation. Conclusion: Compared to individuals with stable state COPD (controls), patients with AECOPD (cases) had higher levels of NLR. Therefore, NLR levels can be used as a marker to predict acute exacerbation, and procalcitonin and hsCRP levels were positively correlated with NLR and PLR levels.
Keywords: COPD, NLR, PLR, Procalcitonin
Edition: Volume 13 Issue 1, January 2024,
Pages: 219 - 221