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Case Studies | Orthopedic | Malaysia | Volume 12 Issue 10, October 2023 | Rating: 4.8 / 10

Clinical Outcome of Dedifferentiated Liposarcoma (DDLPS) in Extremities and Retroperitoneal Areas: A Case Series of 7 Patients

Salahuddin AL | Afif M. Yusof | Hau MA

Abstract: This article explores the clinical outcomes and effectiveness of postoperative radiotherapy in the management of dedifferentiated liposarcoma (DDLPS) in extremities and retroperitoneal regions. DDLPS, a malignant adipocytic neoplasm, presents challenges due to its progression from atypical lipomatous tumour ALT / well - differentiated liposarcomas (WDLPS) to variable - histological grades. The study analyses 7 cases of DDLPS, 4 in extremities and 3 in retroperitoneal areas, focusing on factors such as tumour size, surgical margins, adjuvant therapy, and recurrence rates. In extremities DDLPS, postoperative radiotherapy shows promise for local control, especially with narrow surgical margins, while larger tumour sizes correlate with poorer outcomes. Retroperitoneal DDLPS cases with positive margins exhibit high recurrence rates and limited survival. These findings shed light on potential strategies for optimizing the management of DDLPS in different anatomical locations.

Keywords: dedifferentiated liposarcoma, extremities, retroperitoneal, postoperative radiotherapy, tumour size, surgical margin

Edition: Volume 12 Issue 10, October 2023,

Pages: 1939 - 1941