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Research Paper | Cancer Science | Georgia | Volume 12 Issue 9, September 2023

Role of Melatonin-Microbiome Axis in the Initiation of Carcinogenesis: An Investigation on Disruption of Melatonin Secretion and Structural-Functional Changes of the Microbiome

Alexandre Tavartkiladze ^[2] | Gaiane Simonia ^[2] | Pati Revazishvili ^[2] | Levan Tavartkiladze | Givi Tavartkiladze

Abstract: Background: Melatonin (MT), a ubiquitous hormone across almost all living organisms, is integral to several human physiological functions, including the regulation of the sleep-wake cycle, circadian rhythms, and the functioning of the neuroendocrine and immune systems. It also serves as a significant antioxidant. However, its role in the interplay between the microbiome and carcinogenesis has not been thoroughly explored. Materials and Methods: This study investigates the role of melatonin in microbiome-associated carcinogenesis. We measured melatonin levels in 52 cancer patients (22 women with varying breast cancer stages and 30 men with different prostate cancer stages), along with the presence of Lactobacillus acidophilus and Saccharomyces boulardii. Results: Findings indicate critically low melatonin levels in patients with G3 and G4 dysbiosis, and a significant reduction of these microorganisms. Discussion: The study proposes that melatonin deficiency, accompanied by a selective reduction of Lactobacillus acidophilus and Saccharomyces boulardii, may inhibit sufficient sulforaphane biosynthesis, potentially heightening carcinogenesis risk. Conclusion: Melatonin's potential role in regulating secondary metabolites and carcinogenesis initiation is highlighted, warranting further exploration of this causality

Keywords: Melatonin, Microbiome, Carcinogenesis, Lactobacillus acidophilus, Saccharomyces boulardii, Dysbiosis, Sulforaphane, Oxidative Stress

Edition: Volume 12 Issue 9, September 2023,

Pages: 472 - 475