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Case Studies | Medical Science | India | Volume 12 Issue 7, July 2023
Clinical Profile, Epidemiology & Outcome in Patients with Neuroendocrine Tumour in a Tertiary Care Centre in South India
Dr. Sanjo John | Dr. Akhilandeswari A. R. | Dr. Anand [36] | Dr. K. Premkumar
Abstract: Neuroendocrine tumors (NET) arise from neuroendocrine cells in our body. Any organ in our body might be impacted by NETs. Depending on where they are located, neuroendocrine tumors (NETs) are a group of cancers with various and frequently indolent clinical features. It frequently exhibits vague symptoms, which delays diagnosis. In India, the prevalence of NETs is rising. Objectives: To analyze the epidemiology, clinical profiles, and post - treatment survival outcomes of patients with NET in a tertiary care center in South India. Methods: We analyzed data of 13 patients diagnosed with NET who presented to dept. of Medical Oncology, Govt. Royapettah Hospital and Department of Digestive Diseases and Health, Anna Nagar, Chennai between 2020 and 2022. The clinicopathological profile, treatment, and follow - up data were analyzed. The variables linked to NET - related mortality were discovered using univariate analysis. Results: Men constitute 46.15 % of the population, while women make up 53.85 %. The median age at diagnosis of NET in our study was approximately 58.15 years. A higher proportion of patients with NET were fromrural areas (61.5%) compared with those living in urban areas (38.46%). The most common primary tumor site was the duodenum (46.15%), gastric (15.38%), pancreas (15.38%), rectum (15.38%), and ileum (7.69%) in descending order. Histological grading was done according to mitotic index and Ki - 67 index showing G1 constitutes 69.23%, G2 (15.38%), and G3 (15.38%).2 patients (15.38%) had metastatic lesions. Tumor characteristics and treatment characteristics were assessed. In our study, the overall survival rate at 2 years was found to be 69.23%, and the disease - free survival rate was found to be 53.84%. Conclusion: The factors significantly associated with NET - related mortality were age, primary tumor site, surgical resection status, tumor grade, and clinical stage of the patient.
Keywords: Neuroendocrine tumor, Chennai, duodenum, mitotic index
Edition: Volume 12 Issue 7, July 2023,
Pages: 1659 - 1661