To Study the Role of C-Reactive Protein to Predict the Risk of Pancreatic Necrosis

Doddapaneni Nehasai, Pasala Priyanka

Abstract: Acute pancreatitis is an inflammation of the pancreas of variable severity. Its severity varies from mild to severe attacks like necrotizing pancreatitis which has a poor prognosis. C-reactive protein in an inflammatory mediatory synthesized in the liver and is raised in acute pancreatitis. Aim: To study the role of C-reactive protein in predicting the risk of pancreatic necrosis and other severe complications of acute pancreatitis. Methods: 50 patients admitted to the medical ward with features suggestive of acute pancreatitis from June 2022 to June 2023 were taken for the study. Results: Based on 5th day CRP values 50 patients are divided into 3 groups, 1st group (n-30) CRP less than 100 mg/dl, 2nd group (n-8) CRP level between 100-200 mg/dl, 3rd group (n-12) CRP levels more than 300 mg/dl. The development of necrotizing pancreatitis in correlation with CRP was out of 30 patients in the 1st group, 4 (13.33 %) developed necrotizing pancreatitis, in the 2nd group, out of 8 patients, 4 (50%) developed necrotizing pancreatitis, in the 3rd group, out of 12 patient, all 12 (100%) of them developed necrotizing pancreatitis. Conclusion: CRP levels peaked on the 5th day of illness and a cut-off value of 150 mg/dl can be taken above pancreatic necrosis can be predicted with high probability. This value has a specificity of 80%. CRP values above 200 mg/dl have a specificity of 100%.

Keywords: C-Reactive Protein, Pancreatic Necrosis, inflammation, Acute pancreatitis, and Prognosis