Profiling In-Vitro Drug Release Kinetics from a Bioresorbable Scaffold Implant to Predict In-Vivo Drug Retention in the Treatment of Peripheral Artery Diseases

Minocha Dr. Pramodkumar, Kothwala Dr. Deveshkumar Mahendralal, Lodha Dikshita Yogendrasinh, Ayush Kumar, Desai Mansi Samir

Abstract: Atherosclerosis-induced peripheral artery disease (PAD) frequently leads to significant arterial blockages, necessitating various treatment approaches such as medical management, endovascular interventions, and surgical bypass. This research article introduces a study on an innovative treatment modality for PAD, i.e. the development of Sirolimus Eluting Self Expanding Bioresorbable Braided Peripheral Scaffold System The scaffold comprises a bioresorbable polymer called PLGA, which is coated with an elastomer to facilitate progressive drug release and scaffold biodegradability. Sirolimus, an immunosuppressive drug, is incorporated into the scaffold to mitigate immune reactions during or after implantation. The study primarily focuses on the effective loading and release mechanisms of the drug from the scaffold, as these aspects are pivotal for the success of drug-eluting scaffolds. Through rigorous in-vitro testing, the authors successfully loaded sirolimus onto the scaffold and demonstrated a gradual and sustained release profile over time, which could effectively replicate the in-vivo drug release pattern observed in peripheral arteries. Consequently, the aforementioned Sirolimus Eluting Self Expanding Bioresorbable Braided Peripheral Scaffold System holds promising potential in reducing the risk of restenosis in peripheral arteries.

Keywords: Atherosclerosis, peripheral arteries, restenosis, sirolimus, self-expanding, bioresorbable braided scaffold