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Research Paper | Biochemistry | India | Volume 12 Issue 6, June 2023
Correlation between Serum H2S Level, Oxidative Stress, and Antioxidant Defence in Acute Coronary Syndrome
Prasenjit Pal | Lakshmisona Mallik Auddya | Pinaki Saha | Santanu Sen | Swapan Kumar Halder | Utpal Kumar Biswas
Abstract: Introduction: A number of recent literatures suggest a potential role of H2S and oxidative stress in regulating cardiovascular pathophysiology. Aims and Objective: This study aimed to evaluate the serum levels of hydrogen sulfide (H2S), total oxidative stress (TOS) and total antioxidant defence (TAD) in the patients with acute coronary syndrome (ACS) and explore their correlation. Materials and Methods: Fifty two ACS patients and an equal number of healthy controls were included and serum H2S, TOS and TAD levels were measured. Results: The results showed significantly higher serum H2S and TOS levels and significantly lower TAD levels in ACS patients compared to controls. Positive correlation was observed between H2S and TOS, while negative correlation was found between H2S and TAD in the serum of ACS patients. These findings suggest that increased H2S levels are associated with oxidative stress and decreased antioxidant defence in ACS. Conclusion: The present study has revealed the increase in serum H2S levels in the patients with acute coronary syndrome as the total plasma oxidative stress increases with the subsequent reduction of total antioxidant defence.
Keywords: H2S, Oxidative stress, Antioxidant defence, Acute Coronary syndrome, Kolkata
Edition: Volume 12 Issue 6, June 2023,
Pages: 1879 - 1884