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Research Paper | Biomedical Sciences | India | Volume 12 Issue 6, June 2023

Serum Malondialdehyde Levels in Patients with Non Alcoholic Fatty Liver Disease

Dr. Upama Borah | Dr. Mauchumi Saikia Pathak | Dr. Utpal Deka

Abstract: Background: Non alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the western world and its prevalence is increasing in countries like India. It manifests as a spectrum of disorders starting from simple fatty liver to non alcoholic steatohepatitis (NASH) and cirrhosis. Exact etiology of NAFLD is still under investigation. Malondialdehyde (MDA) is a lipid peroxidation product which can be used as a biomarker for oxidative stress. This study attempts to examine the role of oxidative stress in development of NAFLD. Methods: A case - control study was conducted at a tertiary care hospital in Assam for one year. The study consisted of 70 ultrasound diagnosed patients of NAFLD under the age of 70 years. The control group consisted of 70 healthy volunteers under the age of 70 years. Serum samples were evaluated for MDA in the Department of Biochemistry, GMCH by Enzyme - Linked Immunosorbent Assay (ELIZA). Results: A total of 70 cases and 70 controls were taken up for the study with a mean age of 41.26 and 40.06 years in case and control groups, respectively. The results were analyzed using Graphpad Prism version. The mean value of serum MDA in NAFLD patients is 55.76? 2.92 ng/ml and in control group is 39.66? 2.86ng/ml with p value of <0.0001. Conclusion: MDA levels were significantly higher in NAFLD patients suggesting a state of higher oxidative stress. MDA can be used as biomarker for detection as well as prevention of NAFLD.

Keywords: Non alcoholic fatty liver disease, NAFLD, Malondialdehyde, MDA

Edition: Volume 12 Issue 6, June 2023,

Pages: 1738 - 1740