International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Research Paper | Medicine | India | Volume 12 Issue 7, July 2023

Spectrum of Disease Activity in Incidentally Positive HBsAg Patients in Eastern Uttar Pradesh

Rahul Singh [7] | Mahim Mittal | Bechan Kumar Gautam

Abstract: Introduction: It is estimated that over 40 million hepatitis B-infected subjects account for approximately 10?15% of the entire pool of HBV carriers of the world live in India, and most of the affected population is detected incidentally without any symptoms. Hence, we aimed to evaluate the spectrum of disease activity in incidentally positive HBsAg patients in eastern Uttar Pradesh. Methodology: This prospective observational study included 125 individuals with incidentally detected HBsAg positivity. All participants were given a thorough medical history and general and systemic physical examination. Also performed were a complete blood count, liver function tests, and kidney function tests. Virus-specific markers (HBsAg, HCV and HIV) were also detected. In addition, a USG, Fibroscan and chest x-ray were performed. Results: Most patients with high (80.36%) and low viral load (69.57%) were 18-40 years old. Male preponderance was noted in both groups. The hepatic enzyme levels were higher in patients with high viral load. The mean prothrombin time was significantly higher in patients with a high viral load compared to the low viral load(p=0.0234*). Only 1 patient with a high viral load and 3 with a low viral load had chronic liver disease. The mean fibro scan was insignificantly higher in patients with low viral load. No association was observed between APRI and FIB4 with Fibroscan. Conclusion: Asymptomatic HBsAg was detected incidentally more common in men. Hepatic enzymes and prothrombin time were raised in most patients with a high viral load. Patients with a low viral load had high Fibroscan scores.

Keywords: Hepatitis B virus, hepatitis B surface antigen, incidentally detected HBsAg-positive subjects, Aspartate aminotransferase, Alanine transaminase, Alkaline phosphatase, Fibroscan

Edition: Volume 12 Issue 7, July 2023,

Pages: 371 - 375

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