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Research Paper | Immunology | India | Volume 12 Issue 6, June 2023 | Popularity: 5 / 10

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Correlation of Serum Calcium and Vitamin D on SLE Disease Activity Index among SLE (Systemic Lupus Erythematosus) Patients at a Tertiary Care Centre Structured

Namitha Ann Babu, Aruna R, Suresh MK

Abstract: Background: Systemic Lupus Erythematosus is a prototypic autoimmune disease with diverse multisystem involvement and the production of an array of autoantibodies. The clinical presentation of this disease can be quite variable from mild skin or joint manifestations to life - threatening internal organ manifestation. The SLICC revised ACR criteria are used for the diagnosis of SLE. SLEDAI measures the disease activity based on 24 questions including physical examination, lab features and clinical manifestations. SLEDAI2K measures the disease activity in last 28 - 30 days. Objectives: To find the correlation of serum calcium and vitamin D on SLEDAI and to study the clinical profile of SLE patients. Methods: After obtaining institutional approval 50 SLE patients were enrolled for this study. Patients were interviewed; blood sample was taken for estimation of serum calcium and Vitamin D. Other relevant clinical history and details were collected using preformed questionnaire. The data was entered in to excel sheet and analysed using SPSS 27 software. Results: A negative correlation was associated between Serum calcium, Vitamin D and SLEDAI (Pearson correlation coefficient r= - 0.905 and - 0.50 (p<0.001)). The mean Vitamin D of SLE patients in this study was 11.56+ - 3.6. Cutaneous manifestation and joint manifestations were the predominant presentation. Conclusions: Majority of patients included in the study were Vitamin D deficient. There is a negative correlation between SLEDAI, Serum Calcium and Vitamin D.

Keywords: Systemic Lupus erythematosus, SLEDAI, Calcium, Vitamin D, Correlation

Edition: Volume 12 Issue 6, June 2023

Pages: 636 - 649

DOI: https://www.doi.org/10.21275/SR23604083819

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