Effect of Curcumin in Psoriasis

Makani. Sai Bhargavi | K. Sridevi ^[4]

Abstract: Psoriasis it is a chronic autoimmune & inflammatory non communicable disease. it is usually highly expressed as inflamed red erythematous plaques which is supported by silvery scales. The presence of these scaly patches is an outcome of the unusual proliferation of excessive epidermis, incomplete cornification and preservation of nuclei in cells of statum corneum. The mechanism of action by which curcumin shows as anti-inflammatory response of TNF-stimulated human endothelial cells by interfering with NF-kB. Furthermore, the curcumin is also capable of preventing the platelet-derived growth factor. Curcumin is also to suppress the excessive production of TNF-? by activated macrophages the curcumin has been shown to directly bind to the receptor-binding sites of TNF-? by covalent and non-covalent interactions, blocking the subsequent TNF-dependent activation of NF-k.

Keywords: Psoriasis, Curcumin, Pathogenesis, Plague, Guttate, Inverse, Pustular, Erythrodermic, Koebner

Edition: Volume 12 Issue 8, August 2023,

Pages: 10 - 15