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New Innovation and Idea | Health and Medical Sciences | United States of America | Volume 12 Issue 5, May 2023
A Clinical Trial Evaluating the Efficacy of Prolistem? Supplement in Men with Non-Obstructive Azoospermia (Primary Testicular Failure)
Alona Feldman | Mahmoud Abuelhija
Abstract: Introduction: Non-obstructive azoospermia is a common cause of male infertility and remains one of the most challenging conditions to treat, despite advances in gynecology. Prolistem? is a novel treatment for this condition, which utilizes a unique mechanism called the "Spermatogenesis Restarting Process". Objectives: To evaluate the effectiveness of Prolistem? supplement in the therapy of infertile men with nonobstructive Azoospermia. Methods: Eighty-nine patients with non-obstructive azoospermia were enrolled in the study and received Prolistem? supplement for six months. Hormone parameters, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels, were measured before and after the procedure. Semen analysis was performed after the treatment, and in case of no sperm found, patients were recommended to undergo sperm retrieval techniques such as testicular sperm extraction (TESE) or micro-TESE. All the data required for the study were collected retrospectively from the patients or the hospital records. Results: After six months of Prolistem? supplementation, a significant improvement was observed in the hormone parameters of the patients. The mean FSH level decreased from 18.2 ? 5.6 to 8.4 ? 2.9 mIU/mL (p<0.001), while the mean LH level decreased from 10.1 ? 3.6 to 4.9 ? 2.1 mIU/mL (p<0.001). In contrast, the mean testosterone level increased from 3.6 ? 0.9 to 4.7 ? 1.2 ng/mL (p<0.001). Semen analysis performed after the treatment revealed that 32 patients (36%) had detectable sperm in their semen. Among the 57 patients with no detectable sperm in their semen, 47 patients (83%) underwent sperm retrieval techniques such as TESE or micro-TESE. The sperm retrieval was successful in 32 patients (68%), and viable sperm were obtained for assisted reproductive techniques. Conclusion: There is substantial evidence from both animal models and multiple studies that testosterone exerts an inhibitory effect on spermatogonial differentiation in cases of azoospermia. In the context of non-obstructive azoospermia due to primary testicular failure, Prolistem? supplement has shown promising results as a treatment option.
Keywords: Azoospermia, Male Infertility, Prolistem, Testosterone, Primary Testicular Failure
Edition: Volume 12 Issue 5, May 2023,
Pages: 928 - 936