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Research Paper | Medical Science | India | Volume 12 Issue 4, April 2023
Diagnostic Yield of Routine Distal Duodenal Biopsy in a Tertiary Care Centre in South India (Tamilnadu) - A Retrospective Study
Abstract: Background: Patients with non-diarrheal disease, are highly suspicious for coeliac diseases (CD). To get a clear picture, descending duodenum biopsy remains exclusive. Objectives: To determine the diagnostic yield of routine distal duodenal biopsies in patients with suspected coeliac disease attending a tertiary care centre in Tamil N?du. Materials and methods: A Retrospective study was conducted at department of gastro-enterology at a tertiary care centre in Tamil N?du from January 2018 to June 2021 among 516 suspected CD patients. Demographics, indication for the procedure, preoperative investigations (including complete blood count, and iron studies), endoscopic and histologic findings were collected from medical records. Duodenal biopsies were performed with standard technique using 2.8 mm biopsy taken from D2 second part of duodenum. Data was analysed using SPSS version 22. Results: The mean age was 46.35 ? 14.6 years. There were more proportion of females in the study with 52.52% (271 out of 516). Anemia was reported with high prevalence in 86.82% followed by Diarrhoea 5.81% and Anemia+ diarrhoea in 4.07%. As per endoscopy findings 489 (94.77%) had normal mucosa and scalloping was reported in 19 cases (3.68%). As per the biopsy report 436 (84.50%) cases showed normal mucosa flattening of villi in 5 (0.97%) cases. In abnormal endoscopy 9 (33.33%) cases were suggestive of CS. The difference between biopsy report and endoscopy findings was statistically significant (P value=0.009). The sensitivity of biopsy in predicting celiac was 33.33% (95% CI 16.52, 53.96), specificity was 85.48% (95% CI 82.04, 88.48%) and diagnostic accuracy was 82.75% (79.21, 85.91). Conclusion: Distal duodenal biopsy showed diagnostic accuracy of 82.75% and can be considered in diagnosing suspected CD cases.
Keywords: Iron deficiency anaemia, duodenum, biopsy, endoscopy, small intestine
Edition: Volume 12 Issue 4, April 2023,
Pages: 995 - 998