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Research Paper | Paediatrics | India | Volume 12 Issue 3, March 2023

Therapeutic Hypothermia with Phase-Changing Material in Neonates with Hypoxic-Ischemic Encephalopathy at a Tertiary Care Hospital

Dr. Yelepalem Megha Manasa | Dr. Aparna Lakshmi Yeruva | Dr. P. M. L. Kantha Kumari | Dr. B. Vijayalakshmi

Abstract: Phase-changing material is an alternative, effective and low-cost method of cooling babies sufficient to achieve and maintain the target rectal temperature with fewer adverse effects. The present study was done in a Tertiary care center to assess short-term neurological outcomes in neonates with HIE undergoing therapeutic hypothermia using the HINE score. In the present study, A total of 24 newborns were examined at discharge out of which 5 had abnormal HINE scores. At 1 month of age, 23 infants came for follow-up, of which 5 had abnormal HNNE scores, and 18 had normal scores whereas 1 infant was lost to follow-up. At 2 months of age, 22 infants came for follow-up, of which 4 had abnormal scores, and 18 had normal scores, 2 infants lost to follow-up. At 3 months of age, 22 infants came for follow-up of which 3 had abnormal HINE scores and19 had normal scores, 2 infants lost to follow-up. At 6 months of age, 18 infants came for follow-up of which one infant had abnormal HINE scores, 17 had normal scores, and 6 infants lost to follow-up at this visit. At 9 months of age, 18 infants came for follow-up all of them had normal HINE scores, and 7 infants lost to follow-up at this visit. At 12 months of age, 15 infants came for follow-up all of them had normal HINE scores, and 7 infants were lost to follow-up. A total of 5 babies who had abnormal HINE scores initially were found to be normal in the subsequent visits. To conclude, HINE sequential examination showed better neurological outcomes in asphyxiated newborns who underwent therapeutic hypothermia.

Keywords: HIE, HINE, hypothermia, neonates, rewarming protocol

Edition: Volume 12 Issue 3, March 2023,

Pages: 978 - 982