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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 2, February 2023

Comparison of Atracurium versus Cisatracuruim Regarding Onset Time, Intubating Conditions and Hemodynamic Parameters during General Anaesthesia: A Randomised Control - Single Blinded Study

Dr. Ashish Ameta | Dr Rajan Nanda

Abstract: Introduction: Ideal neuromuscular blocking agent for intubation should have a rapid onset, brief duration of action, free from hemodynamic changes, and provide excellent intubating conditions which reduces the time for intubation and thereby reduces the hemodynamic stress response. Cisatracurium unlike atracurium is devoid of histamine - induced cardiovascular effects and this would be the greatest advantage in replacing atracurium for the facilitation of endotracheal intubation. So study is designated to compare the effectiveness and potency of atracurium and cisatracurium Aim of the Study: to compare the atracurium versus two doses of cisatracurium for intubation conditions with regard to Onset time for intubation, Duration of action, Hemodynamic effects, Complications. Methodology: Study conducted on 60 patients scheduled for GA were randomly divided in three groups with 20 patients in each group: Group 1 ATRACURIUM 0.5MG/KG LD. Group 2 CISATRACURIUM 0.15MG/KG LD. Group 3 CISATRACURIUM 0.2MG/KG LD. Intubating conditions and Hemodynamic perametres with any complication were measured. Results: Optimal intubating conditions were better in cisatracurium group 3 and this difference was statistically significant. P value ?0.041. Conclusion: higher doses of cisatracurium provide more rapid onset, longer duration of action, excellent intubating conditions with hemodynamicaly stable and no signs of histamine release.

Keywords: Atracurium, Cisatracurium, Neuromuscular Monitoring, Intubation

Edition: Volume 12 Issue 2, February 2023,

Pages: 937 - 942