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Study Papers | Cancer Science | India | Volume 12 Issue 1, January 2023

Role of Palliative Radiotherapy to Chest in Advanced Non-Small Cell Lung Carcinoma in Improving Quality of Life and Tumor Response

Dr. Priyanka Gupta ^[2] | Dr. Vishakha Sharma | Dr. Rameshwaram Sharma | Dr. Shivani Gupta | Dr. Ramraj Meena

Abstract: Purpose: Role of Palliative Radiotherapy to chest in advanced Non-Small Cell Lung Carcinoma in improving quality of life and tumor response. Methods and Material: This retrospective comparative dosimetric study is based on the data of patients with histologically proven lung carcinoma treated with palliative radiotherapy to the thorax. Patients were treated with a dose of 30 Gy in 10 fractions at 3Gy per fraction daily six days a week. Radiotherapy is given through cobalt 60 source by conventional treatment. Further, the patients were on follow-up for 3 months and the response was assessed inform of control of symptoms with quality of life after treatment and objective tumor response based on the degree of reduction in the size of tumor on CT scan. The EORTC QLQ-C30 and EORTC QLQ-LC13 questionnaires were used to assess changes in QoL. Assessments were performed before starting radiotherapy and atthe completion of rt & 3 months after rt. Results: Total numbers of Non-Small cell carcinoma lung patients involved in this study are 40 out of which 80% are male and 20% are female. The median age was 65.9 (range 50-75). Out of 40 patients, 4 patients does not report after first visit & 4 patients were not able to complete treatment. So, 32 patients received palliative radiotherapy to the lung. Chest pain and dyspnea at the walk &climbing significantly improved after Radiotherapy when compared to baseline (P<0.001) while cough (P<0.001), hemoptysis (P<0.001) significantly improved after three months of rt in QLQ-LC13 scores. Of the QLQ-C30 scale, Dyspnea significantly improved after radiotherapy when compared to baseline (P<0.001) while fatigue (P<0.05), role functioning (P<0.001) insomnia (P<0.05) and loss of appetite (P<0.001) significantly improved after three months of rt. There is partial tumor response seen by ct scan after 3 months of RT. Conclusion: The present study attempts to analyze the Response of Palliative Radiotherapy to chest and confirms the palliation of respiratory symptoms and improved QoL in a substantial proportion of patients of NSCLC. The mechanism by which palliation of symptoms and improvement of QoL is achieved is through tumor size reduction only.

Keywords: Paliiative Radiotherapy, Non Small Cell Lung Carcinoma, Quality Of Life, Local Control, QLQ-C30 questionnaire, QLQ LC-13 questionnaire

Edition: Volume 12 Issue 1, January 2023,

Pages: 828 - 831

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