Evaluating the Anti-inflammatory Properties of D. Hookeri Rhizome Extract: Insights from an In-Vivo Study

Shubham Wani, Rekha Gour, Anant K. Patel

Abstract: Inflammation occurs as defensive response, which include physiological adaptions to limit tissue damage and remove the pathogenic infections. The ethanolic rhizome extract of D. Hookeri was assessed for its in-vivo anti-inflammatory activity. The unfavourable consequences of synthetic medications for treating acute inflammatory diseases serve as a powerful incentive for scientists to create novel medications with fewer side effects. The soxhlation extraction technique was used to obtain ethanolic extract and the yield of the ethanolic extract of D. Hookeri's rhizomes was 28.27% w/w. The rhizomes of the ethanolic extract of D. Hookeri included alkaloids, saponins, tannins, flavonoids, glycosides, phenolic content, terpenoids, and volatile oils, according to the qualitative preliminary phytochemical screening. The anti-inflammatory efficacy of the ethanolic extract was evaluated against carrageenan induced rat paw edema at different doses (200 and 400mg/kg body weight) orally while indomethacin 10 mg/kg served as standard. The changes in the paw volume of rats were measured using mercury Plethysmometer. The significant anti-inflammatory activity was exhibited in the rats (p

Keywords: Inflammatory activity, Plethysmometer, rhizomes of D. Hookeri, Indomethacin

How to Cite?: Shubham Wani, Rekha Gour, Anant K. Patel, "Evaluating the Anti-inflammatory Properties of D. Hookeri Rhizome Extract: Insights from an In-Vivo Study", Volume 12 Issue 12, December 2023, International Journal of Science and Research (IJSR), Pages: 1250-1254, https://www.ijsr.net/getabstract.php?paperid=SR231215201744, DOI: https://dx.doi.org/10.21275/SR231215201744

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