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Review Papers | Dentistry | India | Volume 12 Issue 12, December 2023
Malicious Interplay between Cells - Role of Osteoimmunology in Alveolar Bone Resorption
K. Malathi [4] | C. Hima Bindu Reddy [2] | Kiruthika A. | Suman Taki | G. Sandhya [2]
Abstract: Periodontal disease is a condition that involves inflammation of the tooth supporting structures. It is initiated in response to plaque and calculus on the tooth surface. The host defence system, both innate and adaptive immunity, is responsible for combating the pathologic microorganisms invading the periodontal tissue. Immune cells activate periodontal ligament cells to express the receptor activator of nuclear factor kappa - B (NF - ?B) ligand (RANKL) and initiate osteoclastic activity. Osteocytes have active roles in periodontitis progression in the bone matrix. Osteoimmunology encapsulates the cellular and molecular mechanisms responsible for inflammatory osteolysis that culminates in the degradation of alveolar bone. It primarily focuses on the interplay of immune cells with bone cells during bone remodelling and regeneration. The concept of osteoimmunology is that immune cells communicate with effector bone cells - the bone resorbing osteoclasts and the bone - forming osteoblasts. This article deals with the interrelationship between the cells of the bone and the immune system and their effect on bone resorption.
Keywords: osteoimmunlogy, Periodontitis, Osteocyte, inflammation, resorption
Edition: Volume 12 Issue 12, December 2023,
Pages: 595 - 598