International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Obstetrics and Gynecology | India | Volume 12 Issue 12, December 2023


Correlation between Lifestyle Factors and Sperm DNA Fragmentation in Infertile Men

Gurbani Kaur Arora | Kundavi Shankar [8] | Yamini Asokan [5] | Geetha V. [2] | Rashmi G. V [2] | Nithya Naaram [5] | Hema Niveda KR


Abstract: Background: The sperm DNA fragmentation index (DFI) is regarded as an important tool but its role in evaluating male infertility still remains controversial. The aim of this study is to evaluate the correlation between sperm DNA fragmentation (SDF) with semen parameters and lifestyle patterns. Methods: In our retrospective study which was conducted at the Institute of Reproductive medicine and women health, Madras medical mission, Chennai from 2019-2023, 120 males with subfertility undergoing treatment were included. DFI was measured using the sperm chromatin dispersion assay (SCD) and based on the results they were divided into 3 groups: Low-DFI ?15%, medium DFI-15%< DFI < 30% and high DFI ?30%. The correlation between DFI and semen parameters were analysed using Spearman?s rank correlation coefficient. Results: In the correlation analysis, DFI showed significant positive correlation with age (p=0.001) and negative correlation with semen parameters like semen volume (p=.0.010), rapid progressive motility (p=0.002) and total motile sperm count (p=0.004). Lifestyle characteristics like body mass index, smoking, consumption of alcohol, diabetes and hypertension showed no significant correlation with DFI. Conclusions: The results indicate a significant relationship between SDF and routine semen parameters, suggesting the inclusion of DNA fragmentation index assessments in male infertility evaluations.


Keywords: Effectiveness, structured teaching program, oral health, tobacco, adolescent


Edition: Volume 12 Issue 12, December 2023,


Pages: 842 - 848


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