Comparative Study of Myringoplasty with and without Autologous PRP in Large Central Perforation

Abstract: Background: Myringoplasty operation is the reconstruction of the tympanic membrane (TM) which is performed to prevent recurrent discharge of the ear and to improve the hearing impairment which is caused by TM perforation. Platelets are the key factors in tissue repair mechanisms. They provide essential growth factors, which stimulate fibroblasts to create extracellular matrix deposition and neovascularization. Aim: This study aims to assess the efficacy of platelet rich plasma(PRP) in myringoplasty with respect to graft uptake and hearing outcome. Materials and Methods: A total of 88 patients diagnosed as COM mucosal inactive disease for more than 6 weeks having large size perforation were divided into groups of 44 each. Patients in group A who underwent myringoplasty with PRP while in second B underwent myringoplasty without PRP. Pre? and post?operative graft uptake and pure tone audiometry were performed for all the patients, and the outcomes were compared. Results: Both groups were statistically matched with regard to age and sex. At three months post-operatively, the success rate (graft uptake) in group A was significantly higher than in group B. The success in terms of graft uptake and hearing outcome was achieved in 40 patients in case group and 37 patients in control group. Conclusion: Topical autologous PRP application during myringoplasty is safe, can be easily prepared, highly efficient and successful with no reported complication. PRP not only enhances healing of chronic TM perforations but also avoids infection.

Keywords: Myringoplasty, PRP, Graft uptake

Edition: Volume 12 Issue 11, November 2023,

Pages: 476 - 480