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Doctoral Thesis | Obstetrics and Gynecology | India | Volume 12 Issue 10, October 2023

Prevalence and Phenotypic Diversity of PCOS in Indian Women: An Observational Study

Dr. Nikeeta Khanorkar | Dr. Pratibha Kulkarni ^[3] | Dr. Eshan Warjukar

Abstract: Aim and objectives: This prospective observational study aimed to investigate the prevalence and phenotypic variations of Polycystic Ovary Syndrome PCOS among Indian women aged 15-35 years, utilizing Rotterdams criteria from 2003 and to study the association between different phenotypes of PCOS and obesity. Methodology: A total of 671 women presenting with irregular menses, clinical hyperandrogenism, or polycystic ovarian morphology were evaluated with help of clinical, biochemical and radiological modality over six months. The study identified four standard PCOS phenotypes A, B, C, D and examined their associations with age, BMI, hirsutism, acne, menstrual irregularities, infertility, and various metabolic and endocrine characteristics. Results: The prevalence of PCOS was highest for phenotype A(HPO;52.57), followed by phenotype D(OP;20.97), phenotype C (HP;15.07), and phenotype B(HO;11.39).PCOS phenotypes exhibited significantly altered endocrine and metabolic profiles compared to controls, with hyperandrogenic phenotypes showing the highest risk for future metabolic disorders. Conclusion: This study underscores the need for vigilant monitoring of women with hyperandrogenic PCOS phenotypes.

Keywords: PCOS, Indian women, Phenotypic diversity, Prevalence, Rotterdam criteria

Edition: Volume 12 Issue 10, October 2023,

Pages: 738 - 748