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Case Studies | Pathology | Indonesia | Volume 11 Issue 9, September 2022
Primary Ovarian Non-Hodgkin Lymphoma Diffuse Large B-Cell, Anaplastic Variant
Ni Made Mahastuti [2] | Mellinda Wijaya | Ni Putu Sriwidyani [8] | Putu Erika Paskarani
Abstract: Introduction: Non Hodgkin's lymphoma may involve gynecologic tract. Secondary involvement by NHL from the other site is often occurred as part of systemic disease and ovary is the more common site to be involved. However, primary ovarian NHL is very rare. Case description: a 31 year old woman complained of abdominal pain, fever and shortness of breath. Abdominal ultrasonography reveals a large solid mass of the right ovary and multiple paraaortic lymphadenopathy. There was a significant increase in serum CA-125 and LDH. Frozen section examination was conducted and found a gelatinous, yellowish-white color, solid ovarian mass, 11x7, 5x4, 5cm in size that filled the entire tissue. Microscopically, the cells arranged in a diffuse pattern and had an anaplastic morphology. Mitoses were numerous. The conclusion of the frozen section was a malignancy, tends to be Germ Cell Tumor. The diagnosis was then confirmed by routine histopathology examination and found diffuse, solid sheets and linear anaplastic cell tumor. Differential diagnosis of Non Hodgkin Lymphoma, Undifferentiated carcinoma and Embryonal carcinoma were made and immunohistochemical examination was done. The results showed as follow: CD45 and CD20 were diffusely positive, TdT and CD3 was negative and Ki67 was positive in 90% tumor cells. Conclusion: Based on histopathology and immunohistochemical examination, this case was concluded as Non-Hodgkin?s lymphoma, diffuse large B cell, anaplastic variant, stage IIIE. This patient has a total IPI score of 4 and a poor prognosis. The patient was reported dead.
Keywords: ovarian tumor, anaplastic cell, non hodgkin lymphoma, immunohistochemistry
Edition: Volume 11 Issue 9, September 2022,
Pages: 894 - 898