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Research Paper | Pathology | India | Volume 11 Issue 9, September 2022
Histopathological Study of Prostatic Lesions (TURP) at Tertiary Care Centre
Abstract: Introduction: Diseases of prostate gland are important source of morbidity and mortality in male patients. The spectrum of dis?eases consists of inflammatory conditions, nodular hyperplasia, malignancy etc. The risk of diseases increases with age. Pros?tate biopsy is essentially a test which detects cancer and other benign conditions of the prostate. Aims and Objective: To study various histopathological patterns in TURP, including benign prostatic hyperplasia (BPH), prostatitis (identifying type and grade of inflammation), and incidental detection of carcinoma prostate and confirmation of diagnosis of clinically suspected carcinoma with application of modified Gleason system for grading. Materials and Methods: Total 100cases of transurethral resection of prostate (TURP). The received biopsies were fixed in 10% neutral buffered formalin and routine paraffin processing followed by haematoxylin and eosin staining was done. Slides of the tissues were retrieved and slides reviewed. All the specimens were analysed with following parameters: age of patient, histopathological pattern and final diagnosis. Results: In total 100 cases of present study, the most common age group presenting prostatic lesions was 61 - 70 years. The youngest patient presented at age of 41 years and oldest was of 86 years of age. In our study, among various histopathological patterns, BPH was the most common finding and reported 5 cases of adenocarcinoma of prostate with application of modified Gleason grading system. Conclusion: Among the histological patterns of prostatic lesions, BPH is predominant type. It is necessary to study all prostate biopsy [Transurethral resection of prostate (TURP) ] in order to identify premalignant lesions, proliferative activity, and grade of inflammation. Histopathological diagnosis and grading is gold standard for the final diagnosis and have a definitive role in the management of prostatic carcinoma.
Keywords: Transurethral resection of prostate, TURP, Benign prostatic hyperplasia, BPH, Prostate Carcinoma
Edition: Volume 11 Issue 9, September 2022,
Pages: 874 - 878