Downloads: 11
Research Paper | Pharmacology and Toxicology | Volume 11 Issue 9, September 2022 | Pages: 224 - 231 | Nigeria
Fasting Blood - Glucose Lowering Effect of Dacryodes Edulis Seeds Extract
Abstract: Background: D. edulis seeds extract is used in the management of hyperglycemia in folkloric medicine but with limited scientific justification. Method: The obtained n - hexane seed extract of D. edulis (NSEDE) was used to carry out acute toxicity (LD50), phytochemical and anti - diabetic studies. Albino rats (20) divided into 4 groups (n=5) were used for anti - diabetic study. Diabetes was induced using Alloxan monohydrate (i. p) at the dose of 150 mg/kbw. Distilled water (10 ml/kg) and Metformin (500 mg/kg) served as negative and positive control respectively. The other two groups received NSEDE 250 and 500 mg/kg (P. O) respectively. Fasting blood sugar levels were recorded at hourly intervals and thereafter on 2nd, 4th, 6th, 8th, 10th, 12th, and 14th day. A histopathological examination of the pancreas was carried out. Results: NSEDE was safe up to the dose of 5000 mg/kg/bw. There was abundance of secondary metabolites. From the 2nd hour, a significant (P
Keywords: D edulis seeds, fasting blood sugar, diabetic rats
How to Cite?: Victoria N. Umeh, Jude N. Okoyeh, "Fasting Blood - Glucose Lowering Effect of Dacryodes Edulis Seeds Extract", Volume 11 Issue 9, September 2022, International Journal of Science and Research (IJSR), Pages: 224-231, https://www.ijsr.net/getabstract.php?paperid=SR22821232655, DOI: https://dx.doi.org/10.21275/SR22821232655