International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


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Research Paper | Medicine | Indonesia | Volume 12 Issue 1, January 2023


Differences of N-Mid Osteocalcin and Magnesium Levels in Severe and Not Severe Osteoarthritis

Rinaldi Kurniawan Lubis | Otman Siregar | Ricke Loeshinari


Abstract: Background: Osteoarthritis (OA) is a degenerative joint disease, characterized by erosion of articular cartilage. OA is the most common form of arthritis and a major cause of pain and disability. Recently, the potential use of biomarkers for the diagnosis and monitoring of osteoarthritis has been widely used. Various biomarkers, such as C- or N-propeptide of type II procollagen; N-propeptide from type I and type III collagen; collagen type II neoepitope; C-telopeptide from type I and type II (CTX-II) collagen; Matrix metalloproteases, C-reactive protein, N-MID Osteocalcin and magnesium have previously been explored for use in the diagnosis of OA. Methods: This research is an observational study with cross sectional data collection method. This study took blood samples from patients with severe OA and non-severe OA who came to the Orthopedic Surgery and Traumatology Polyclinic as many as 35 patients. Samples were checked only once for N-MID Osteocalcin and Magnesium. The research was conducted after obtaining ethical approval and informed consent. Result and Discussion: There were 30 female subjects (85.7%). The mean age of the subjects was 64.17 years with the youngest age being 48 years and the oldest being 80 years. Using the Independent T test showed that there was no significant difference in magnesium levels based on the severity of osteoarthritis (p = 0.226). Using the Independent T test showed that there was no significant difference in N-Mid Osteocalcin levels based on the severity of osteoarthritis (p = 0.212). Conclusions and suggestions: There was no significant difference in the levels of N-Mid Osteocalcin and Magnesium based on the severity of osteoarthritis. Further research is needed to involve subjects with more varied characteristics in osteoarthritis patients.


Keywords: Osteoarthritis, N-Mid Osteocalcin, Magnesium


Edition: Volume 12 Issue 1, January 2023,


Pages: 142 - 145


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