Association between Inflammatory Cytokines, and Growth Factors in Early Detection and Progression of Colorectal Cancer

Mohammed Abdulrahman Alshahrani

Abstract: Background: Prevalence of colorectal cancers (CRC) is continuously elevating during the recent last decades. Objective: The main aim of this survey was to study the association between inflammatory cytokines, interleukins and growth factors in early detection and progression of colorectal cancer. Methodology: A total of 300 subjects (150diagnosed patients with CRC as cases + 150 healthy persons as controls) were included in this study. Growth factors and cytokines levels had been determined in all participated subjects' serum by using Luminex Technology Multiplex Assay (ELISA). A logistic regression analysis had been used for determining the association between CRC and plasma interleukins' levels after adjusting for some potential confounding factors. Results: 60% of the studied population were Saudis. Male?: ?female ratio was 8?: ?7. Subjects' age ranged from 45 to 86 years (mean ?SD: 64.4 ? 9.6). The mean body mass index (BMI) was 24.1?kg/m2 (?2.9). Significant differences were observed in the mean plasma levels between the CRC patients and controls for 13 plasma cytokines, namely IL-4, IL-8, IL-9, IL-17A, Eotaxin, G-CSF, IFN-?, TNF-?, IP-10, MIP-1?, MIP-1?, IFNG, and RANTES (p < 0.05). Conclusion: The significant elevation of serum inflammatory cytokines and growth factors in CRC patients suggesting the strong association and crucial role in early detection of CRC in humans.

Keywords: Inflammatory Cytokines, Growth Factors, Early Detection, Progression of Colorectal Cancer

How to Cite?: Mohammed Abdulrahman Alshahrani, "Association between Inflammatory Cytokines, and Growth Factors in Early Detection and Progression of Colorectal Cancer", Volume 11 Issue 3, March 2022, International Journal of Science and Research (IJSR), Pages: 286-291, https://www.ijsr.net/getabstract.php?paperid=SR22304041346, DOI: https://dx.doi.org/10.21275/SR22304041346