Association between Inflammatory Cytokines, and Growth Factors in Early Detection and Progression of Colorectal Cancer

Mohammed Abdulrahman Alshahrani

Abstract: Background: Prevalence of colorectal cancers (CRC) is continuously elevating during the recent last decades. Objective: The main aim of this survey was to study the association between inflammatory cytokines, interleukins and growth factors in early detection and progression of colorectal cancer. Methodology: A total of 300 subjects (150diagnosed patients with CRC as cases + 150 healthy persons as controls) were included in this study. Growth factors and cytokines levels had been determined in all participated subjects' serum by using Luminex Technology Multiplex Assay (ELISA). A logistic regression analysis had been used for determining the association between CRC and plasma interleukins' levels after adjusting for some potential confounding factors. Results: 60% of the studied population were Saudis. Male?: ?female ratio was 8?: ?7. Subjects' age ranged from 45 to 86 years (mean ?SD: 64.4 ? 9.6). The mean body mass index (BMI) was 24.1?kg/m2 (?2.9). Significant differences were observed in the mean plasma levels between the CRC patients and controls for 13 plasma cytokines, namely IL-4, IL-8, IL-9, IL-17A, Eotaxin, G-CSF, IFN-?, TNF-?, IP-10, MIP-1?, MIP-1?, IFNG, and RANTES (p < 0.05). Conclusion: The significant elevation of serum inflammatory cytokines and growth factors in CRC patients suggesting the strong association and crucial role in early detection of CRC in humans.

Keywords: Inflammatory Cytokines, Growth Factors, Early Detection, Progression of Colorectal Cancer