Lymphocytes as Predictor of Severity in COVID19

Dr. Neha A

Abstract: The outbreak of the COVID-19 has led to various studies to determine the correlation between severity of the disease and decreased lymphocytes in patients of COVID 19. The increase in monocyte-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, and marked increase in levels of cytokines, such as IL-2R and its ratio to lymphocyte count, correlated with severity of the disease and poor outcomes. Although the pathophysiology involved in COVID-19 has not yet been clearly known, an insight into the underlying mechanisms that lead to the observed lymphopenia can be helpful for understanding the disease pathogenesis and would help in better management of such patients. Here we briefly discuss the clinical significance of lymphopenia that sets in during the course of COVID-19 and the mechanism behind it to determine if these changes holds any significance to the prognosis, which would help us in understanding of the disease better and would lead to the discovery of new therapeutic options of the patients of COVID-19.

Keywords: COVID-19, lymphopenia, disease severity, cytokines, therapeutic options

How to Cite?: Dr. Neha A, "Lymphocytes as Predictor of Severity in COVID19", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 733-734, https://www.ijsr.net/getabstract.php?paperid=SR22119181843, DOI: https://dx.doi.org/10.21275/SR22119181843