Downloads: 66 | Views: 183
Masters Thesis | Biomedical Sciences | Indonesia | Volume 10 Issue 1, January 2021
The Administration of Oralwhite Tea (Camellia sinensis) Extract Reduced Tumor Diameter Size of Breast Carcinoma and Head/Necksquamous Cell Skin Carcinoma in Female Sprague Dawley Strain Rat (Rattus norvegicus) Induced by 7,12 Dimethylbenz-(?)Anthracene (DMBA)
Vitti Erwin | Wimpie Pangkahila [22] | Anak Agung Ayu Ngurah Susraini [6]
Abstract: Background: In women, the most common type of carcinoma is breast carcinoma. Head/neck skin carcinoma with the most common carcinoma is squamous cell carcinoma, which is a non-melanoma skin malignant tumor originating from the suprabasal epidermal keratinocytes. White tea (Camellia sinensis) is tea that comes from very young tea leaves that are still rolled up when picked and protected from the sun thereby contains the highest levels of polyphenols and caffeine. One of the functions of polyphenols is antioxidants and can trigger apoptosis in carcinoma cells. Method: Randomized pretest-posttest only control group design, using 10 female Sprague Dawley rats as research subjects. Subjects which were positive for tumors after being induced with DMBA were divided into two groups (control and treatment). The control group received a placebo ( 0.5 ml aquabidest) while the treatment group received 100 mg/kg body weight of white tea extract. The extract and placebo were given orally once a day for 21 days. Measurement of carcinoma tumor diameter was carried out before and after treatment. The results obtained are processed using software. Result: The comparative analysis showed that the mean tumor diameter in the control group was 9.80 mm (± 4.15 mm), and in the treatment group was 7.60 mm (± 2.88 mm). There is a difference of 2.20 mm (3.01 mm to 7.41 mm). This difference was not significant with a p value = 0.359. After treatment, the results of the comparative analysis showed that the mean tumor diameter in the control group was 19.00 mm (± 3.08 mm) while in the treatment group was 14.60 mm (± 2.30 mm). These results indicate that there is a difference of 4.40 mm (1.43 to 8.37 mm). This difference is significant with a p value = 0.034. Conclusion: Administration of white tea (Camellia sinensis) extract orally reduced the tumor diameter size of breast and head/neck skin carcinoma of female Sprague Dawley strain rat (Rattus norvegicus) induced by DMBA.
Keywords: white tea, Camellia sinensis, breast carcinomas, head and neck skin carcinomas, diameter size of carcinomas, DMBA
Edition: Volume 10 Issue 1, January 2021,
Pages: 1105 - 1108