International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 119 | Views: 158

Research Paper | Medicine Science | United Kingdom | Volume 9 Issue 6, June 2020

Examination of Cognitive Deficits Produced by Sub-Chronic Ketamine Exposure in Rats

Christopher Wood [2] | Mohammed Shoib

Abstract: Chronic NMDA receptor suppression by NMDA antagonists (ketamine), induce structural changes in neocortical and limbic brain regions, resulting in similar cognitive deficits to that observed clinically in schizophrenia. Objectives: This study was designed to evaluate cognitive deficits following ketamine administration in rodents, assessed through an attentional set-shifting paradigm. Thus, allowing evaluation of cognitive flexibility in the form of discrimination acquisition, reversal learning and intra/extra-dimensional shifts (ability to switch between dimensions). Methods: Forty four male Lister Hooded rats, underwent a five day daily sub-chronic treatment regime prior to habituation. The three treatment groups where; VEH, ketamine (10mg/kg, IP) and ketamine (30mg/kg, IP). Rats underwent habituation two days post treatment cessation, consisting of a simple odour and medium discrimination.24 Hours later, rats were assessed on a attentional set shifting task. Results: Sub-chronic ketamine treatment impaired reversal learning in a dose dependent manner. Animals treated with ketamine (30mg/kg), required significantly more trials to criterion for all three reversal trials (REV1-3). Ketamine (10mg/kg) treatment significantly impaired acquisition during REV2. Ketamine (30mg/kg) treated rats made significantly more errors during each reversal (REV1-3). A clear trend emerged between ketamine exposure and latency; rats treated with ketamine (30mg/kg) required longer to complete REV1 to EDS. Ketamine (30mg/kg) treatment resulted in a significant deficit in the acquisition of the odour and medium tasks, during habituation. Conclusion: These results show sub-chronic ketamine treatment impairs reversal learning. Our findings support the impairments observed clinically following CANTAB assessment in schizophrenic patients. Hence, our data suggests sub-chronic ketamine treatment results in similar cognitive deficits. Our results support the hypothesis that ketamine is an important pharmacological compound to model cognitive deficits in rats.

Keywords: Schizophrenia, Chronic Ketamine, Set-shifting, Rat

Edition: Volume 9 Issue 6, June 2020,

Pages: 1893 - 1903

How to Download this Article?

Type Your Email Address below to Download the Article PDF

Text copied to Clipboard!
Christopher Wood, Mohammed Shoib, "Examination of Cognitive Deficits Produced by Sub-Chronic Ketamine Exposure in Rats", International Journal of Science and Research (IJSR), Volume 9 Issue 6, June 2020, pp. 1893-1903,

Click below to Watch Video Lecture of Above Article


Share this Video Lecture

Similar Articles with Keyword 'Schizophrenia'

Downloads: 117

Research Paper, Medicine Science, Bulgaria, Volume 7 Issue 4, April 2018

Pages: 1267 - 1269

Onychomycosis among Patients with Schizophrenia and Comorbid Substance Use Disorders

Petranka Chumpalova [3] | Valentin Valtchev [4] | Maya Stoimenova-Popova [2] | Ludmil Tumbev [2]

Share this Article

Downloads: 120

Research Paper, Medicine Science, India, Volume 3 Issue 5, May 2014

Pages: 516 - 522

Knowledge; Attitudes and Practices among Caregivers of Patients with Schizophrenia in Western Maharashtra

Mahadeo Shinde [26] | Amol Desai [2] | Shivaji Pawar

Share this Article