Antifertility Activity of Low Dose of Alcoholic Extract of Vinca rosea (Catharanthus roseus) (L.) Leaves in Female Swiss Albino Mice

Preeti Gupta

Abstract: This study investigated the antifertility potential of a 5 mg/day oral dose of the alcoholic extract of Vinca rosea (L. ) leaves in adult female Swiss albino mice. Vinca rosea (also known as Catharanthus roseus, Madagascar Periwinkle, or Apocynaceae) is traditionally known for its medicinal properties, including those affecting reproductive health. The extract was administered to female mice post-coitally to evaluate its effect on pregnancy. Results demonstrated a significant reduction in implantation rate, suggesting potent anti-implantation activity and possibly anti-estrogenic activity. Biochemical analysis of the uterus revealed altered levels of key reproductive markers like glycogen and cholesterol, which can be linked to the extract's mechanism of action.

Keywords: antifertility activity, Vinca rosea extract, reproductive health, implantation inhibition, biochemical analysis

How to Cite?: Preeti Gupta, "Antifertility Activity of Low Dose of Alcoholic Extract of Vinca rosea (Catharanthus roseus) (L.) Leaves in Female Swiss Albino Mice", Volume 5 Issue 7, July 2016, International Journal of Science and Research (IJSR), Pages: 2263-2265, https://www.ijsr.net/getabstract.php?paperid=SR16710152121, DOI: https://dx.doi.org/10.21275/SR16710152121