Creatine Kinase for Prognostication in Organophosphorus Poisoning

Dayanand Raddi, Anikethana G V

Abstract: Organophosphorus poisoning is the responsible for a significant morbidity and mortality in agrarian countries. The incidence of poisoning is higher in young, economically active group with a case fatality rate of 10-20 %. Our study was done to evaluate the prognostic significance of Creatine kinase in organophosphorus poisoning. During the study period a total of 360 poisoning cases were admitted to the hospital of which 80 were eligible for the study. The mortality in patient with elevated creatine kinase was 39.47 % as against 4.76 % in patients with normal creatine kinase. It was statistically significant. Ventilator requirement in patients with elevated creatine kinase was statistically significant (44.74 % vs 9.52 %). The study emphasizes the role of creatine kinase in prognostication of patients presenting with organophosphorus poisoning.

Keywords: creatine kinase, organophosphorus poisoning, acute poisoning, severity of poisoning, modified Dreisbach criteria