Effect of L-carnitine on Lead-induced Infertility in Female Rats
Abstract: The correlation between lead toxicity and infertility was confirmed in many studies. The present study aimed to explore the effect of L-carnitine on the adverse effects caused by lead metal on female rat fertility. Animals were organized into four groups (negative control group, lead acetate positive control group (50mg/L), L-carnitine low dose group (50mg/Kg Bwt/day) and L-carnitine high dose group (100mg/Kg Bwt/day). After 21 day period of treatment blood samples were collected and female rat ovaries were excised for Estradiol quantitative estimation and CYP19a1 gene expression respectively, samples were collected related to the four phases of the estrous cycle. The results of the present study revealed that lead metal in a dose of (50mg/L) causes significant decreases (p
Keywords: Lead toxicity, female rat fertility, Estrous cycle, CYP19a1 gene, Estradiol, L-carnitine
How to Cite?: Gamal Galal, Tarek Abou Zed, Khalid Kahilo, Mustafa Shukry, "Effect of L-carnitine on Lead-induced Infertility in Female Rats", Volume 5 Issue 2, February 2016, International Journal of Science and Research (IJSR), Pages: 1492-1499, https://www.ijsr.net/getabstract.php?paperid=NOV161415, DOI: https://dx.doi.org/10.21275/NOV161415