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Research Paper | Medicine Science | Volume 4 Issue 11, November 2015 | Pages: 2427 - 2434 | Albania
Host Factors Influences on Treatment Response in Chronic Hepatitis C Patients Treated with pegINF and Ribavirin in Albania
Abstract: Introduction The impact of viral factors like genotype, HCVRNA at baseline, or viral kinetics during treatment of chronic hepatitis C patients is better defined recently. In contrary different results comes from studies about the impact of age, gender or BMI on treatment response in chronic hepatitis C (CHC) with standard scheme. Aim To evaluate the predictive value of host factors (age, gender, BMI, biochemical and hematological profile) on treatment response in CHC patients in Albania. Patients and methods A total of 151patients, diagnosed with CHC in UHC Mother Tereza service of Gastro-Hepatology were included in this study. All the patients were treated with PegINF alfa-2a (180 g s. c/week) and ribavirin 800-1200 mg/day (according to body weight and genotype). The duration of treatment varied from 24-48 to72 weeks according to genotype and virological response. Patients were assessed for age, gender, BMI, TC (total cholesterol), TGC, Fast blood glucose (FBG), GGT, AST, ALT, WBC, PLT, HB and was evaluated their impact on treatment response in both SVR and Non-SVR group. Data were analyzed statistically by Chi square test and T test. P / = 27 kg / m2, are 2.6 times more likely than patients with BMI
Keywords: hepatitis C, host factors, treatment, impact
How to Cite?: Anila Kristo, Dr. Jovan Basho, Nikollaq Leka, Dr. Elizana Petrela, Jonila Cela, "Host Factors Influences on Treatment Response in Chronic Hepatitis C Patients Treated with pegINF and Ribavirin in Albania", Volume 4 Issue 11, November 2015, International Journal of Science and Research (IJSR), Pages: 2427-2434, https://www.ijsr.net/getabstract.php?paperid=NOV151732, DOI: https://dx.doi.org/10.21275/NOV151732