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Analysis Study Research Paper | Anaesthesiology | Volume 14 Issue 9, September 2025 | Pages: 1169 - 1172 | India
Effect of 6% Hydroxyethyl Starch Pre-Administration for Reduction of Pain on Propofol Injection: A Randomized Controlled Trial
Abstract: Background: Pain on propofol injection has been a matter of concern over the years. However, even with multi-modal techniques, pain on propofol injection is not abolished completely. Colloids modify the vascular endothelium and prevent contact activation of various substances. Pre administration of colloids may prevent contact activation of vascular endothelium by propofol. Aims and Objectives: To study the effect of 6% HES on the incidence of pain on propofol injection, and occurrence of any adverse reaction. Materials and Methods: This double blinded randomized study included 68 patients of the ASA I and II patients and 18-65 years old who underwent elective surgery. The patients were randomised into two groups: who received either 100ml bolus of 6% HES (n=34) or 100 mL bolus of placebo 0.9% normal saline (n=34). Comparison of demographic characteristics, pain during propofol injection, and adverse effects was done. P-value
Keywords: Adverse reaction, HES, Injection, Pain, Propofol
How to Cite?: Fedry Singh B, Valsamma Abraham, "Effect of 6% Hydroxyethyl Starch Pre-Administration for Reduction of Pain on Propofol Injection: A Randomized Controlled Trial", Volume 14 Issue 9, September 2025, International Journal of Science and Research (IJSR), Pages: 1169-1172, https://www.ijsr.net/getabstract.php?paperid=MR25920090001, DOI: https://dx.doi.org/10.21275/MR25920090001