Factors Affecting Leak in Primary Intestinal Anastomosis: A Comprehensive Analysis
Abstract: Anastomotic leakage (AL) remains one of the most serious complications of primary intestinal anastomosis, significantly contributing to postoperative morbidity, prolonged hospitalization, and increased mortality. With incidence rates reported between 3% and 20% and mortality reaching up to 30% in high-risk groups AL is a multifactorial problem influenced by patient-related, surgical, and intraoperative factors. This paper reviews key determinants affecting anastomotic integrity, including vascular perfusion, tension, surgical technique, patient comorbidities (such as diabetes, obesity, and immunosuppressive therapy), and postoperative care. We analyze current literature, risk stratification models, and clinical case series to highlight evidence-based strategies?ranging from preoperative optimization and intraoperative imaging (e.g., ICG fluorescence) to emerging technologies like robotic surgery and bioengineered scaffolds that reduce leak rates and improve surgical outcomes.
Keywords: anastomotic leakage, intestinal anastomosis, risk factors, surgical complications, bowel surgery
How to Cite?: Dr. Ganesh Swami, Dr. Pancham Patodekar, Dr. Sagar Kalwale, Dr. Sandeep Jadhav, "Factors Affecting Leak in Primary Intestinal Anastomosis: A Comprehensive Analysis", Volume 14 Issue 4, April 2025, International Journal of Science and Research (IJSR), Pages: 409-411, https://www.ijsr.net/getabstract.php?paperid=MR25404124032, DOI: https://dx.doi.org/10.21275/MR25404124032