The Impact of NSAIDs on Osseointegration: A Comprehensive Analysis of Clinical Data and Therapeutic Implications

PH. Yasmeen Ayoub Alkhawaldeh, Dr. Mahmoud Reda Alkhawaldeh, Dr. Yazan Bassam Shdefat, Dr. Rami Tayseer Alomari, Dr. Ahmad Subhi Younes

Abstract: Dental implantology often prescribes NSAIDs for postoperative pain and inflammation, clinical and scientific efforts continue to study their impact on osseointegration, the biological process that determines implant success, the COX enzyme pathway, which NSAIDs target, is necessary for prostaglandin production and bone metabolism, raising important considerations concerning the balance between pain treatment and healing, this study analyzes clinical data from 182 dental implant cases and reviews current evidence on NSAIDs' effects on osseointegration, mechanisms of action, therapeutic protocols, and clinical implications for implant success rates. The clinical data from 182 dental implant cases performed between October 2023 and January 2025 on Jordanians in Mafraq city at King Talal Military Hospital was retrospectively analyzed, systematic data was collected on patient demographics, implant features, treatment regimens, and results, the research protocol was ethical and institutionally approved, patient identity, implant specifications, surgery dates, prosthesis delivery timeframes, laboratory data, and clinical observations were collected, patterns and relationships between variables and implant results were examined using statistical analysis, the clinical dataset showed 182 implants in varied patient demographics, 4 failures, and 3 compensated cases, producing a 96.2% success rate. Crown and bridge restorations were the main treatment methods, with different healing times and prosthesis loading regimes, laboratory agreements with Orange, Ramada, Bani Yasin, Al-Zeitouna, and GF indicated standard prosthetic procedures among providers, clinical observations revealed patients requiring sinus lift surgeries and bone grafting, highlighting the complexity of implant treatment in impaired anatomical situations, when properly handled, dental implant treatment may achieve high success rates in difficult clinical circumstances, NSAIDs may affect osseointegration, thus dose, duration, and timing must be carefully considered, current research indicates that short-term NSAID use (?7 days) may not significantly impact osseointegration, but prolonged use may affect bone repair, dental providers must balance risks and advantages when prescribing NSAIDs for implant treatment, the short-term regimens appear to relieve pain without affecting osseointegration, but long-term usage should be avoided, research should focus on developing evidence-based NSAID recommendations for implant dentistry, taking into consideration patient-specific variables, implant characteristics, and healing needs, clinical research ethics were followed throughout this study, assuring patient consent and data security.

Keywords: NSAIDs, osseointegration, dental implants, cyclooxygenase inhibitors, bone healing, prostaglandin synthesis, implant success, postoperative pain management, COX-2 inhibitors, titanium implants, alveolar bone, osteoblast function, inflammatory response, clinical outcomes

How to Cite?: PH. Yasmeen Ayoub Alkhawaldeh, Dr. Mahmoud Reda Alkhawaldeh, Dr. Yazan Bassam Shdefat, Dr. Rami Tayseer Alomari, Dr. Ahmad Subhi Younes, "The Impact of NSAIDs on Osseointegration: A Comprehensive Analysis of Clinical Data and Therapeutic Implications", Volume 14 Issue 10, October 2025, International Journal of Science and Research (IJSR), Pages: 1231-1238, https://www.ijsr.net/getabstract.php?paperid=MR251021002858, DOI: https://dx.doi.org/10.21275/MR251021002858