Downloads: 6 | Views: 110 | Weekly Hits: ⮙1 | Monthly Hits: ⮙6

Research Paper | Biochemistry | India | Volume 13 Issue 3, March 2024

Prevalence of Subclinical Hypothyroidism in Untreated PCOS Patients and PCOS Patients on Metformin at a Tertiary Care Hospital of Eastern India

Dr. Madhushree Pahari | Dr. Mousumi Mukhopadhyay | Dr. Sambhunath Bandopadhyay

Abstract: Background: There is increasing evidence suggesting that PCOS is linked to the increased prevalence of thyroid diseases, especially subclinical hypothyroidism. This study aims to compare the prevalence of subclinical hypothyroidism in untreated PCOS patients with age - matched, diagnosed PCOS patients on metformin therapy for >6 months. The aim is to establish the effect of metformin on thyroid hormone status in patients with PCOS on metformin therapy for >6 months as compared to patients with PCOS without metformin therapy. Aims: To compare the prevalence of subclinical hypothyroidism in untreated PCOS patients with age - matched, diagnosed PCOS patients on metformin therapy for >6 months, in order to establish the effect of metformin on thyroid hormone status in patients with PCOS patients on metformin therapy for >6 months. Material and Methods: Serum TSH, FT4, and FT3 of all patients were measured. The study was conducted in the Department of Biochemistry and Department of Gynaecology in IPGME&R, Kolkata from February 2020 to July 2021 (18 months). Results: The mean TSH level of metformin - treated PCOS was 3.29?2.73 and among untreated was 4.15?3.28. There were no significant differences of FT4 and FT3 between the two groups. Conclusion: The metformin - treated PCOS group had a significantly lower mean TSH level than the untreated PCOS group (t198=2.02; p=0.022).

Keywords: Polycystic Ovary Syndrome, Subclinical Hypothyroidism, Metformin

Edition: Volume 13 Issue 3, March 2024,

Pages: 833 - 839