LUPUS Cerebritis in SLE / SJOGREN'S Overlap Syndrome

Dr. Avneet Kumar, Dr. Ganesh Prasad

Abstract: This article reports on a rare case of lupus cerebritis in an 18 - year - old female, presenting with acute neurological symptoms and diagnosed against the backdrop of systemic lupus erythematosus SLESjogrens overlap syndrome, a type of mixed connective tissue disease MCTD. The patient exhibited symptoms such as seizures, altered sensorium, and autonomic dysregulation, without evident meningeal irritation or infection. Despite normal imaging and basic laboratory findings, cerebrospinal fluid analysis and specific autoantibody profiles confirmed the diagnosis. Treatment with intravenous glucocorticoids led to significant improvement within four days, followed by maintenance therapy. This case underscores the complexity of diagnosing neuropsychiatric manifestations of autoimmune diseases, particularly in the context of MCTD, and emphasizes the importance of comprehensive evaluation and management in such patients. It highlights the critical role of recognizing overlap syndromes in autoimmune diseases for prompt and effective treatment, showcasing the intricacies of autoimmune pathophysiology and the necessity for vigilant follow - up and personalized care.

Keywords: Systemic Lupus erythematous, Sjogern's Syndrome, Lupus Cerebritis, Mixed Connective tissue Disease, Autoimmune Neuropsychiatric Disorders

How to Cite?: Dr. Avneet Kumar, Dr. Ganesh Prasad, "LUPUS Cerebritis in SLE / SJOGREN'S Overlap Syndrome", Volume 13 Issue 3, March 2024, International Journal of Science and Research (IJSR), Pages: 141-142, https://www.ijsr.net/getabstract.php?paperid=MR24301105545, DOI: https://dx.doi.org/10.21275/MR24301105545