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Analysis Study Research Paper | Medicine | India | Volume 12 Issue 9, September 2023
The Association between Serum Sodium Level, Incidence and Severity of Complications in Liver Cirrhosis
Uday Vadicherla | Shubha Immaneni | P. Ratnakar Kini [2]
Abstract: Introduction: Sodium (Na) is one of the essential elements in the body. It is important for the functioning of cells and transport of water and minerals across cell membranes. Hyponatremia is one of the most common electrolytic disturbances in Decompensated liver cirrhosis. Several studies have reported that lower serum Na levels were associated with increased complications and mortality leading to incorporation of Na in the MELD - Na score. Aim: To evaluate the association between serum Na level and severity of complications in liver cirrhosis. Methods: A total of 275 patients who presented to our institute with cirrhosis of liver with over a period of 18months were analyzed. At admission, all selected patients were examined and clinical findings noted and laboratory investigations were done. Baseline MELD - Na score was calculated. Based on serum Na value, subjects were divided into three groups: Group - 1 (Na level <120mEq/L), group - 2 (Na level 120 - 125mEq/L) and group - 3 (126 - ? 130mEq/L) and were assessed for 90 - day mortality rates. The areas under the receiving - operator characteristic curve (AUROC) were calculated for mortality. Results: Mean age was 42.87?5.58 years; 247 were males (89.8%) and 28 were females (10.2%). Based serum Na level, 13 patients were classified into group - 1 (4.7%), 38 patients into group - 2 (13.8%), and 224 patients into group - 3 (81.5%). Four patients had MELD - Na score ?9 (1.5%), 13 had MELD - Na score 10 to ?19 (4.7%), 154 had MELD - Na score 20 to ?29 (56%), 97 had MELD - Na score 30 to ?39 (35.3) and 7 had MELD - Na score ?40 (2.5). The AUROC for predicting 90 - day mortality was 0.770 and 0.990 for serum Na level and MELD - Na scores, respectively. Conclusion: Serum Na level can be taken as simple indicator for predicting 90 - day mortality and complication in patients with liver cirrhosis, but is not superior to MELD - Na.
Keywords: hyponatremia, serum sodium, MELD - Na, cirrhosis
Edition: Volume 12 Issue 9, September 2023,
Pages: 2104 - 2108