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Case Studies | Medical Science | India | Volume 12 Issue 6, June 2023

Omeprazole Induced Chronic Cough in a Non - Smoking Indian Woman

Niladri Sekhar Dingal

Abstract: Objective: To report a case of persistent non productive chronic cough due to omeprazole therapy in a non - smoking Indian woman of middle age. Case summary: A 38 years old Indian woman presented with persistent non - productive chronic cough due to omeprazole which was initiated due to dyspepsia. Nature of the cough was dry, persistent, non - spasmodic. Primary diagnosis was done as Gastroesophageal Reflux Disease (GERD) and omeprazole continued for 2 months. Later other cough related workups had been done to know the cause of chronic cough, but couldn?t get any answer. After literature search omeprazole discontinued and ranitidine started for dyspepsia. Finally cough resolved after omeprazole discontinuation. Discussion: Asthma, post nasal drip, GERD etc are most common causes of non - productive chronic cough in non - smokers. Although drug induced chronic cough also been reported in many patients. Among them Angiotensin Converting Enzyme Inhibitors (ACEi) are most common, mostly 40%. Though package insert of omeprazole doesn?t include this adverse event. In this patient temporal relationship was present and causality was probable. Though the mechanism was not clear. Conclusion: Chronic dry cough can be seen as a result of omeprazole therapy. Prescriber and consumer both should be aware of this adverse drug reaction.

Keywords: adverse drug reaction, omeprazole, chronic cough, dry cough

Edition: Volume 12 Issue 6, June 2023,

Pages: 544 - 545