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Analysis Study Research Paper | Pediatrics | India | Volume 12 Issue 3, March 2023
To Study the Association between Severity of Perinatal Asphyxia and Multiorgan Dysfunction
Yendeti Bharath Vyass | Veedha Sree Jasti | Gokul Krishnan R. | Kedarnath Reddy T.
Abstract: Background: Perinatal asphyxia is a leading cause of neonatal mortality and survivors are at risk for neuro- developmental sequelae including motor and cognitive disabilities. Many clinical, pathological, biochemical and metabolic changes occur as a result of perinatal asphyxia which affect many organ systems like CNS, CVS, RS, renal, adrenal, GIT, skin and haemopoetic systems. The study was designed to study the association between the severity of perinatal asphyxia and multiorgan dysfunction. Aim and Objectives: To study the association between severity of perinatal asphyxia and multiorgan dysfunction. Methods: This was a hospital based prospective observational study that was carried out at inborn NICU of tertiary care hospital attached to Narayana medical college and hospital during the period of April 2022 - October 2022 (6months). Methodology: Inborn perinatal asphyxia babies were recruited as per study protocol. Immediately after birth of an asphyxiated newborn, 1 mL of blood was collected in heparinised syringe from double clamped segment of umbilical cord for Arterial Blood Gas Analysis (ABG). All the asphyxiated newborns were shifted to neonatal intensive care unit (NICU) after resuscitation for further monitoring and management. Screening and staging of Hypoxic Ischemic Encephalopathy (HIE) was done as per Sarnat and Sarnat staging system. The admitted newborns were observed for immediate outcome during first 24 hours of life and classified as neurologically normal or abnormal based on signs of HIE. All the cases were followed up till the discharge or death for final outcome. The association of severity of perinatal asphyxia and multiorgan dysfunction is evaluated and analysed statistically. Results: Among the 48 babies included in the study, the mean APGAR at 1 minute is 3 and at 5 mins is 4, the mean PH is 7.01. Among the study population, 26 babies are categorised into severe asphyxia, 12 into Moderate asphyxia and 10 into mild asphyxia after correlating with mean APGAR score at 1mins, 5 mins and PH. Incidence of Multiorgan dysfunction was observed in 21asphyxiated babies, various complications were developed in 20babies without multiorgan dysfunction. Relative risk and attributable risk was calculated which showed significant association between severity of perinatal asphyxia and multiorgan dysfunction. Conclusion: There is a significant association between the severity of perinatal asphyxia and multiorgan dysfunction with poor outcome.
Keywords: Birth asphyxia, APGAR score, Hypoxic ischemic encephalopathy, Multiorgan dysfunction
Edition: Volume 12 Issue 3, March 2023,
Pages: 473 - 475