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Research Paper | Anaesthesiology | India | Volume 12 Issue 2, February 2023
Comparison of Hemodynamic Changes and Blood Sugar Levels between Etomidate and Propofol Before and after Induction of General Anaesthesia
Das Dhanjit | Borah Pollov [4] | Saikia Arunima [2] | Swargiri Kannauj [3] | Gohain Swapnanil
Abstract: Sudden hypotension, arrhythmias, and cardiovascular collapse are threatening complications following injection of induction agent in hemodynamically unstable patients. This study aims to compare the hemodynamic changes and blood sugar levels between etomidate and propofol following the induction of general anaesthesia. Methods: This is ahospital based observational study, where 90 patients of either sex, between 18 - 60 years of age belonging to ASA grade I and II, scheduled for elective surgeries under general anaesthesia were selected consecutively. The patients were divided into two groups, Group E (n= 45) patients who received etomidate and Group P (n=45) patients who received propofol as induction agent. Study parameters including heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded during induction and then at 1, 2, 3, 4, 5, 10 and 15 minutes after induction. Blood sugar were recorded before and after induction. The side effects were observed. Results: Hemodynamic parameters at 2, 3, 4, and 15 minutes post induction were significantly more stable in Group - E than Group - P (p - value<0.05). After induction there is significantly rise inblood sugar in Group - E compared to Group - P (p - value=0.0090). Higher number of patients had hypotension and bradycardia in Group - P compared to Group - E though it was not statistically significant. And lower number of patients had nausea and vomiting in Group - P compared to Group - E which was also not statistically significant. Conclusion: Etomidate is hemodynamically more stable than propofol. After induction blood sugar levels in the etomidate group were found to be somewhat higher than the propofol group from the baseline level.
Keywords: Etomidate, propofol, hemodynamic changes, blood sugar
Edition: Volume 12 Issue 2, February 2023,
Pages: 1614 - 1618