Downloads: 2 | Views: 76 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Review Papers | Medicine | India | Volume 12 Issue 10, October 2023
Inflammatory Mediators in Multiple Sclerosis: Targets for Therapeutic Intervention
Yekkala Anjaneya Abhiram | Praneeth Ulavala [14] | C. Prabhakar Raju [11]
Abstract: Multiple sclerosis (MS), a chronic autoimmune disease, is characterised by a complex interplay of inflammation and demyelination within the central nervous system. This article delves comprehensively into the intricate landscape of inflammatory mediators in MS, elucidating their multifaceted roles, underlying mechanisms, and their potential as promising therapeutic targets. In the pursuit of effective treatments, understanding these dynamic mediators is paramount. Inflammatory mediators in MS form an orchestra, with pro-inflammatory cytokines like interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-?) as conductors, orchestrating the immune system's assault on myelin. Chemokines, such as CXCL12, act as sirens, guiding immune cells to the battleground. T cells and macrophages emerge as key actors in this autoimmune drama. This section unravels the complex network of these mediators and explores their intricate contributions to the demyelination and neurodegeneration that hallmark MS. Furthermore, biomarkers of inflammation, including cerebrospinal fluid markers and advanced neuroimaging techniques, stand as diagnostic and monitoring tools, affording a deeper understanding of disease progression and treatment efficacy. Emerging therapeutic strategies targeting inflammatory mediators are poised to transform MS management. Disease-modifying drugs, monoclonal antibodies, and innovative immunomodulatory approaches aim to quell inflammation and arrest disease progression. However, challenges such as long-term immunosuppression safety, personalised medicine, and combination therapies must be navigated. In conclusion, inflammatory mediators hold a pivotal role in the MS narrative. As researchers journey further into this domain, optimism rises for more effective, tailored interventions, illuminating a path toward improved quality of life for those grappling with this intricate and often challenging condition.
Keywords: Multiple sclerosis, Biomarkers, Neurodegeneration, chronic autoimmune
Edition: Volume 12 Issue 10, October 2023,
Pages: 797 - 799