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Research Paper | Biomedical Sciences | Nigeria | Volume 8 Issue 4, April 2019
Changes in Some Reproductive Hormones Levels of Stress Induced Albino Rats Treated with Aqueous Extracts of Syzygium Aromaticum
Kebbi John Perewarebo | Brown Holyand Ebirien | Agana Samuel Bartimaeus [3]
Abstract: The correlation between a stress exposed or a stress induced lifestyle and the etiology of reproductive challenges has come into focus, knowing that exposure to stress can lead to overproduction of reactive oxygen species which is the leading factor in the development of oxidative stress. Syzygium aromaticum extracts have been discovered to increases sperm count but excessive intake caused damages to the testicular tissues and can reduce the oxidative stress in the body. This study examined changes in some reproductive hormones of stress induced rats exposed to Syzygium aromaticum. Seven-two (72) albino rats comprising of 36 male and 36 female rats were used for the study. The Seven-two (72) were divided into six groups, consisting of three treatment groups of eight male and female albino rats. And a control group made up of four males and females. The control group was made up of the baseline group, positive control and a negative control group. The positive control received hormones analogs and feeds while the negative control did not receive any treatment apart from feeds. The treatment groups were given different dosages of 100mg/kg, 250mg/kg and 500mg/kg of Syzygium aromaticum aqueous extract orally for 28days. All the rats were exposed to stress using the Analgesymeter which induced pain except the baseline control group. After the experimental duration, all the rats were sacrificed and blood samples collected and tissues harvested. This was followed by assaying the levels of some reproductive hormones. The result revealed that the reproductive hormones of all the various extract groups of male rats exposed to Syzygium aromaticum extract were significantly higher than the baseline and negative control except for the maximum dosage at p< 0.05). Similar trend was observed for the female rat. This study brought to bear that Syzygium aromaticum extract has the tendency of increasing reproductive hormone at minimal doses, but may retard reproductive hormone at higher doses.
Keywords: oxidative, stress, reproductive, hormone, Syzygium aromaticum
Edition: Volume 8 Issue 4, April 2019,
Pages: 886 - 889