International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 164 | Views: 215

Comparative Studies | Medical Science | India | Volume 8 Issue 3, March 2019


Comparison of Two Different Doses of Dexmedetomidine in Decreasing the Extubation Response

Roshni Sebastian | Harshavardhan K


Abstract: BACKGROUND: Laryngoscopy, intubation and extubation is associated with sympathetic stimulation which results in hypertension and tachycardia. Drugs modulating the sympathetic response can be used during extubation to decrease the sympathetic response AIM: To compare of two different doses of dexmedetomidine in decreasing the sympathetic response. . METHOD: A hospital based Prospective, randomized, double blind study where a total of 66 patients undergoing surgery under general Anaesthesia in our hospital were randomly divided into 2 groups: Group-D1: Dexmedetomidine (0.25mcg/kg) group 33 patients; Group-D2: Dexmedetomidine (0.5mcg/kg) group 33 patients. The hemodynamic parameters, airway reflexes were assessed in different intervals of time and compared. RESULT: heart rate and systolic and diastolic blood pressure were significantly lower in D2 group (0.5 g/kg) as compared to D1 group (0.2 g/kg). Smooth extubation was reported in 93.9 % cases of D2 group as compared to 81.8 % in D1 group. Rough experience was seen in 18.2 % cases of D1 group as compared to 6.1 % in D2 group (p-0.25). Mean time for extubation was significantly lower in D2 group (136.7 vs 224.5 sec; p


Keywords: extubation, dexmedetomidine, sympathetic response


Edition: Volume 8 Issue 3, March 2019,


Pages: 380 - 383


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