International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 134 | Views: 195

Comparative Studies | Medical Surgical | India | Volume 8 Issue 1, January 2019


Application of Tranexamic Acid in Total Knee Replacement Surgeries

Sandra Everest | Radhesh Hegde [6]


Abstract: Total knee replacement surgeries are associated with perioperative blood cell transfusions and a higher rate of postoperative morbidity and mortality. Perioperative antifibrinolytic therapy is recommended to reduce blood loss. This study was conducted on a total of 30 subjects randomly divided into two groups of 15 patients each. The first group (Group T) received Tranexamic acid (15 mg/kg of body weight mixed in 100 ml normal saline). The second group (Group P) received a bolus of an equivalent volume of placebo (normal saline), 10 minutes before the deflation of the pneumatic tourniquet respectively. Our study showed that Group P lost almost five times more blood during the recovery phase and twice the volume of Group T in the surgical ward. Based on the results of the present study, we concluded that use of Tranexamic Acid significantly reduces blood loss caused by TKR performed with a tourniquet


Keywords: Tranexamic acid, blood loss, anemia, coagulation


Edition: Volume 8 Issue 1, January 2019,


Pages: 1392 - 1394


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